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Loneliness is associated with depressive symptoms and with a variety of negative health outcomes in both humans and rodents. Furthermore, social isolation increases the expression of two proteins in the hypothalamic paraventricular nucleus (PVN) (CRH and AVP) that are thought to be involved in appetite regulation. If loneliness causes an increase in AVP and CRH expression it might be expected that rats exposed to loneliness as young adults would show increased sensitivity to dietary protein deprivation (PD). We tested the hypothesis that social isolation leads to increased sensitivity to PD in adult rats using plasma urea as an index of PD. On p. 33-35, young (2 months of age) male rats were housed either with/or without a companion in a group of 4 (social isolation) or singly (isolated) for four weeks. On p. 66-68, young (2 months of age) male rats were kept socially isolated or in a group of 4 for four weeks. Rats were then weighed, then placed in a metabolic cage. On p. 72, rats were given water only for 24 hr and placed in the metabolic cage once again. Plasma urea was measured in samples collected every 4 hr for the first 24 hr of PD and every 12 hr for the second 24 hr. Rats housed in groups were less sensitive to PD than were socially isolated rats. Young rats who were socially isolated as adults showed increased sensitivity to PD than those housed with a conspecific.Cognitive effects of mesenchymal stromal cells in a mouse model of epilepsy.
There is a growing interest in the therapeutic potential of mesenchymal stromal cells (MSC) for several neurological disorders. The transplantation of these cells into neuroinflammatory or neurodegenerative disorders may have several effects, such as the restoration of microenvironment, control of inflammation, improvement of neuronal viability and anti-inflammatory effects. Epilepsy is a chronic disease characterized by recurrent spontaneous seizures that can be accompanied by cognitive dysfunctions. The cognitive impairment associated with epilepsy is a severe problem for patients. Several experimental studies have revealed that MSC can be beneficial for the prevention of epilepsy-related cognitive changes. Here, we review studies of MSC effect on cognition in